ABSTRACT
The cleft lip and palate (CLP) is one of the most common craniofacial malformations in humans. We collected functional magnetic resonance data of 23 CLP patients before rehabilitation training (Bclp) and 23 CLP patients after rehabilitation training (Aclp), who were performing Chinese character pronunciation tasks, and performed brain activation analysis to explore the changes of brain mechanism in CLP patients after articulation disorder rehabilitation training. The study found that Aclp group had significant activation in the motor cortex, Broca area, Wernicke area and cerebellum. While the Bclp group had weak activation in the motor cortex with a small activation range. By comparing the differences and co-activated brain regions between the two groups, we found that rehabilitation training increased the activity level of negatively activated brain areas (cerebellum, left motor area, Wernicke area, etc.) to a positive level. At the same time, the activity level of weakly activated brain areas (right motor area, Broca area, etc.) was also increased. Rehabilitation training promoted the activity level of articulation-related brain regions. So that the activation intensity of articulation-related brain regions can be used as a quantifiable objective evaluation index to evaluate the effect of rehabilitation training, which is of great significance for the formulation of rehabilitation training programs.
Subject(s)
Humans , Articulation Disorders/therapy , Brain/diagnostic imaging , Cleft Lip/diagnostic imaging , Cleft Palate/diagnostic imaging , Magnetic Resonance Imaging , Speech Therapy/psychologyABSTRACT
Objective@#To study the mutual effect of EPHA3 gene polymorphism, folic acid intake in early pregnancy, and the occurrence of non-syndromic cleft lip with or without cleft palate, so as to provide the oretical basis for a etiological study on non-syndromic cleft lip with or without cleft palate.@*Methods@#A total of 195 patients and 170 controls were included.The candidate site rs7650466 was genotyped by Snapshot technique.The correlation with folic acid intake in early pregnancy was analyzed.@*Result@#The rs7650466 T allele was highly associated with the pathogenesis of non-syndromic cleft lip with or without cleft palate(OR=0.2472, 95%CI=0.1567-0.3899, P=1.851×10-9). The T allele had protective effects.Folic acid intake in early pregnancy, and its interaction with EPHA3 gene, were associated with the pathogenesis of this disease(P<0.05).@*Conclusions@#EPHA3 gene, folic acid intake during the first trimester, and theinteractionsare associated with the pathogenesis of non-syndromic cleft lip with or without cleft palate.
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<p><b>OBJECTIVE</b>Convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and low intake of folic acid by the mother during pregnancy. The present study was designed to explore if genetic variation in the betaine-homocysteine methyltransferase (BHMT) gene contributes to NSCL/P.</p><p><b>METHODS</b>DNA was obtained from 166 individuals with NSCL/P and 285 healthy subjects. Three known single nucleotide polymorphisms (SNPs) present in the BHMT gene (rs651852, rs3797546, and rs3733890) were investigated by real-time PCR-based TaqMan genotyping.</p><p><b>RESULTS</b>Neither allelic nor genotypic association was found between NSCL/P and SNPs rs651852 and rs3733890. SNP rs3797546 did not show allelic association with NSCL/P; however, a higher proportion of NSCL/P patients carry the CC genotype compared with the TT+CT genotype (P=0.020, OR=2.10, 95% CI=1.11-3.95).</p><p><b>CONCLUSION</b>Our study suggests that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner.</p>
Subject(s)
Humans , Asian People , Genetics , Betaine-Homocysteine S-Methyltransferase , Genetics , Metabolism , Case-Control Studies , China , Cleft Lip , Genetics , Cleft Palate , Genetics , Gene Expression Regulation , Genetic Predisposition to Disease , Genotype , Polymorphism, Single Nucleotide , Risk FactorsABSTRACT
@#ObjectiveTo observe the clinical effect of titanium plate osteosynthesis in jaw bone fracture.Methods26 cases were treated with titanium plate, and the function of recovery were analyzed.ResultsAfter operation, the patients recovered in phase Ⅰ except one who was malocclusion, periodontium and temporomandibular were affected rarely. It did not limited mouth open; the time of functional recovery was very short.ConclusionThe effect of titanium rigid internal fixation shows well.
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Objective To investigate the phonological characteristics of patients with functional speech problems. Methods Ninety patients with functional speech problems were classified by speech analysis. All types of speech problems were analyzed. Results The functional speech problems can be categorized as unaspiration, palatalization, lateralization, fronting of tongue, backing of tongue, plosion, omission of consonants, glottal stop, affrication and backing of tongue and nasalization. Backing of tongue and nasalization was only related to the consonant l, and the unaspiration was often related to such consonants as p, t, k, q, c, ch. Conclusion The functional speech problems were related to consonants. There was regularity with the involvement of the consonants in different types of functional speech problems.
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<p><b>OBJECTIVE</b>To investigate the phonological characteristics of glottal stop on the patients with speech disorders following cleft palate surgery or pharyngoplasty, and to determine the effects of a new method of speech training for glottal stop in chinese.</p><p><b>METHODS</b>Using the methods of listening judge and sound spectrograph in acoustic analyses to investigate the category and frequency of glottal stop on consonants in Chinese. A new method of speech therapy was used for 12 patients with glottal stop.</p><p><b>RESULTS</b>The frequency of glottal stop on the unaspirating affricates and unaspirating plosives were the highest in Chinese consonants. Secondly, the aspirating affricates and aspirating plosives, and then, the fricatives, but the nasal consonants were not effected by glottal stop completely. The score of articulations of the 12 patients whom trained through the methods increased from 32% to 85.5%.</p><p><b>CONCLUSIONS</b>The glottal stop is one of the main causes to impair the articulations of consonants and speech. The new methods of speech training for glottal stp are effective.</p>
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Cleft Palate , General Surgery , Glottis , Phonetics , Speech Disorders , Therapeutics , Speech Therapy , Methods , Treatment OutcomeABSTRACT
Objective:To explore a good method which might be used to reconstruct the nasal deformity after unilateral complete cleft lip has been repaired. Methods: After being folded into a small column, the conchal cartilage was transplanted into nasal columella to reconstruct the frame of the nasal columella so that the nasal tip was supported strongly. Then the bilateral columella cartilages were raised to its normal and symmetrical position and then sutured to the conchal cartilage column. After that, a "Z" plasty was made on the ridge of nasal mucosa under nostril on the side of the cleft. Results: A total of 44 cases were treated by the method above, and above 90% of cases were evaluated as satisfactory. Conclusion:It is a good method to reconstruct the nasal deformity by transplanting conchal cartilage into nasal columella.